Typically, architects and designers focus on designing physical space while scientists focus on understanding the unknown and unseen. Often, these lines of vision and discovery do not cross. In contrast, the Institute for Health in the Built Environment works on projects that integrate designers, scientists and industry partners to explore the unseen elements of our built environment, including the indoor microbiome, air, chemistry, thermal and visual comfort, perception, psychologic and physiologic response, to understand how to better design for health. We use science to design the unseen.